In Diablo 2 Resurrected, finding uniques, sets and those sorts of this items is generally going to be a little bit easier for a lot of the cases, as the D2R Runes have more just randomness to them overall, especially the high level runewords, but there are still some tips you can do to improve your chances of finding them, so let's go ahead and dive in.
Black Marsh Rune Farming
In Act-1 of Diablo 2, Black Marsh is an excellent place to farm runes. Towers in the Black Marsh area can provide you with a good number of runes.
In Nightmare and Hell, locate the Forgotten Tower in Black Marsh. Nightmare and Hell are recommended because, with them, the quality of the rune improves.
Step into the Forgotten Tower. Once you’ve entered, go all the way up to level 5. As you progress to level 5, enter the room next to the level 5 Entrance. You’ll have to deal with several minions here.
Take them out. You’ll see the Countess once the minions are out of the way. Take her out as well, and depending on your luck, she’ll drop between 1-3 runes.
There’s also a good chance that you’ll find a gem or two. At most, she’ll drop 6 runes per kill.
The Arcane Sanctuary
Arcane Sanctuary is another place where you can expect to obtain good high-level Runes. We all know this as the area where we find the which is the real tomb of Tal Rasha, out of all the seven we find throughout the desert.
All the ghosts in this place have a limited drop pool, so by killing them, you automatically have a higher chance of dropping runes.
However, if you want to improve your chances, make sure not to kill them off the path, and also check the end of the paths for additional chests.
These chests carry high-level loot within them, including these highly desired Runes, which can make the difference.
Another spot where you can try your luck is Tal Rasha’s tomb, where you find the last boss of Act 2, which is Duriel. He too can drop some pretty good ones, if you are lucky.
The council has a good chance of dropping high runes in Diablo 2 Resurrected. They can be tricky to kill, but if you can clear these guys with ease, they can drop all sorts of the good loot and high runes are included in that drop table. If you don't have a character they can deal with those quickly, that might not be the best D2R rune farming spots for you step on this list.
Hellforge’s Quest is the second quest of Act4. The completion of the quests grants a rune reward, which allows players to get mid-tier runes early in the game. On Normal Difficulty up to Amn rune, on Nightmare Difficulty from Sol to Um rune, and on Hell Difficulty from Hel to Gul rune can be found by completing the quest. All runes provided by the quest have an equal chance of dropping.
Farming Secret Cow Level
Secret Cow Level is a great location for farming high runes, because of monster density the more monsters you kill the better chance you get of dropping high runes. You're going to be pumping up the drop rates of just regular white cows if you're playing single-player, unfortunately, there are a lot of good budget characters that can clear cows pretty efficiently. Because of mass monster density more monsters, you kill more chances you get dropping items, and then those drops could potentially be hybrids so make sure you farm lots of the Secret Cow Level.
The Countess in Hell difficulty is located in the Forgotten Tower and will always drop at least one rune, which has a slight chance of it being a higher leveled rune. She can’t drop all runes, though. The highest rune the Countess can drop in Hell difficulty is up to a Lo rune.
Brushing runes is also a very interesting thing. If you don't have enough time to do it, then you can also choose to quickly Buy Diablo 2 Resurrected Ladder Items from https://www.igvault.com/Diablo-2-Resurrected-Items